Endocrine Abstracts

Tyrosine kinase inhibitors (TKIs) are relatively new therapy drugs used for the treatment of metastatic cancers including Renal cell carcinoma (RCC), gastrointestinal stromal tumours, thyroid and neuroendocrine tumours. They block vascular endothelial growth factor and other growth factors Thyroid dysfunction is often a side effect of this treatment. A close monitoring of thyroid hormone levels is a necessity.We have a case of a 69-year-old lady with RCC...

Positive interference in free thyroxine (fT4) and free triiodothyronine (fT3) immunoassays is well known, however we report a rare case of negative interference in the Roche fT4 and fT3 immunoassays in a 3-year-old girl with undetectable fT4 and fT3. She presented with increasing tiredness, abdominal pain, pain in her lower limbs and constipation. Examination was unremarkable. Thyroid func...

Introduction: Sclerochoroidal calcification is an uncommon condition that classically manifests as multiple discrete yellow placoid lesions, often discovered as an incidental finding. It is ordinarily believed to be idiopathic, but is also associated with primary hyperparathyroidism. It is important that these patients are identified because of the systemic implications and treatable nature of these disorders.Case: 82 years old patient with history of Pr...

Introduction: Phosphoenolpyruvate carboxykinase (PEPCK) is the key rate determining enzymes of gluconeogenesis pathway. PEPCK exists in cytosolic (PEPCK-C) and mitochondrial (PEPCK-M) isoforms. PEPCK isoforms maintain glucose/lipid homeostasis and is being explored as a therapeutic target for treating metabolic diseases. We tested the influence of a naturally occurring compound Genistein (a soy derived isoflavone) to constitutively regulate PEPCK isoforms to address its potent...

Background: The only available SGLT2 inhibitor in Nepal till date is empagliflozin. Empaglilozin has shown to be cardioprotective and renoprotective in randomized trials. It has shown to reduce some weight. There is a lack of data of SGLT2 inhibitors in Nepalese Type 2 diabetes patients.Aim: The aim of our study is to determine the effects of empagliflozin in glycemic control in terms of HbA1C reduction, weight, improvement in eGFR and side effect profil...

Hyperperhomocysteine has been implicated in vascular changes and oxidative stress contributing to endothelial dysfunction in preeclampsia. Our earlier studies have shown increased oxidative stress leading to reduced docosahexaenoic acid (DHA) levels in pre-eclamptic women. The present study examines the levels of angiogenic factors (VEGF, PlGF sFlt-1), homocysteine and oxidative stress marker malondialdehyde (MDA) levels, in 90 normotensive (control) and 137 preeclamptic women...

Diabetes, one of the most commonly seen metabolic disorders, is affecting a major area of population in many developing as well as most of the developed countries and is becoming an alarming concern for the rising cost of the healthcare system. Latent Autoimmune Diabetes in Adults (LADA) is a form of diabetes which is less recognized and under diagnosed type of diabetes which appears to have characteristics of both type 1 (autoimmune in nature) and type 2 diabetes (adult age a...

The aim of study was to recurrently follow quality of life in type 1 diabetes patients after multiple educations and counseling. Ninty six patients of the age group of “between” 10 to 25 were initially examined in 2004 and Eighty eight patients of them were reexamined in 2006 after multiple counseling with diabetologist and trained diabetes educator at dia care, Ahmedabad, Gujarat, India. Quality of life was defined as perceived well being and life satisfaction, glob...

The study was aimed to compare the outcome of pregnancies in women with type 1 diabetes treated with continuous subcutaneous insulin infusion pump (CSII) or multiple insulin injections (MDI). Total 14 patients were treated with insulin pump and 20 patients were treated with multiple injections; were mainly investigated for HbA1c, incidence of hypoglycemia, fetal outcome, rates of pregnancy induced hypertension and cesarean section. HbA1c with insulin pump was significantly bet...

Renal impairment and electrolyte disorders in hypothyroidism are frequently subtle and rarely observed in clinical practice. Case reports have noted the association but it is rarely found in textbooks. We describe a case of new onset renal dysfunction secondary to hypothyroidism. A 54-year-old male was referred to renal clinic with new renal failure. He described a 3 weeks history of sudden onset peri-orbital, facial and generalised leg swelling and associated muscle ache and ...